Toxic effects in C57B1/6 and DBA/2 mice following consumption of halogenated aromatic hydrocarbon-contaminated Great Lakes coho salmon (Oncorhynchus kisutch Walbaum).
نویسندگان
چکیده
Diets containing coho salmon (Oncorhynchus kisutch Walbaum) from the Pacific Ocean or from Lakes Erie, Michigan, and Ontario [containing a gradation from low to high of halogenated aromatic hydrocarbons, (HAHs)] were fed to C57B1/6 and DBA/2 mice. Following a 4-month dietary exposure to Lake Ontario salmon, both strains of mice demonstrated hepatomegaly. The ethoxyresorufin-O-deethylase (ERR) enzyme levels were elevated in livers of C57B1/6 mice fed diets of salmon from all of the Great Lakes studied, with exceptionally high levels detected in C57B1/6 mice fed Lake Ontario salmon. Induction of ERR enzyme levels was detected in DBA/2 mice only following dietary exposure to Lake Ontario salmon. Serum levels of L-thyroxine (T4) and triiodo-L-thryonine (T3) were suppressed in C57B1/6 mice following consumption of Lake Ontario coho salmon, but T3 and T4 levels remained unchanged in DBA/2 mice. In general, pathobiological effects correlated with both dietary HAH exposure level and Ah receptor status.
منابع مشابه
X-cell lesions in the liver of coho salmon Oncorh vnch us kisutch
A coho salmon Oncorhynchus kjsutch (Walbaum) was found to develop lesions associated with so called X-cells propagating in the liver parenchyma. The ultrastructural features, insufficient to determine the origin of X-cells, corresponded to those found in pseudobranchial tumours of Atlantic cod by Watermann & Dethlefsen (Helgolander Meeresunters. 35: 231-242, 1982).
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 75 شماره
صفحات -
تاریخ انتشار 1987